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An Essential Role for Nuclear Factor κB in Promoting Double Positive Thymocyte Apoptosis

To examine the role of nuclear factor (NF)-κB in T cell development and activation in vivo, we produced transgenic mice that express a superinhibitory mutant form of inhibitor κB-α (IκB-α(A32/36)) under the control of the T cell–specific CD2 promoter and enhancer (mutant [m]IκB-α mice). Thymocyte de...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Hettmann, Thore, DiDonato, Joseph, Karin, Michael, Leiden, Jeffrey M.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: The Rockefeller University Press 1999
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC1887697/
https://ncbi.nlm.nih.gov/pubmed/9874571
Tagiau: Ychwanegu Tag
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