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Conformational variability of the intracellular domain of Drosophila Notch and its interaction with Suppressor of Hairless

The Notch receptor is the central element in an evolutionarily conserved signal transduction pathway that controls cell fates in metazoans. Receptor–ligand interactions trigger a cascade of proteolytic events that release the entire Notch intracellular domain (NICD) from the membrane, permitting its...

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Hlavní autoři: Kelly, Deborah F., Lake, Robert J., Walz, Thomas, Artavanis-Tsakonas, Spyros
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2007
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC1887580/
https://ncbi.nlm.nih.gov/pubmed/17535912
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0702887104
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