Oxygen metabolism and reactive oxygen species cause chromosomal rearrangements and cell death

The absence of Tsa1, a key peroxiredoxin that functions to scavenge H(2)O(2) in Saccharomyces cerevisiae, causes the accumulation of a broad spectrum of mutations including gross chromosomal rearrangements (GCRs). Deletion of TSA1 also causes synthetic lethality in combination with mutations in RAD6...

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Bibliographische Detailangaben
Hauptverfasser: Ragu, Sandrine, Faye, Gérard, Iraqui, Ismail, Masurel-Heneman, Amélie, Kolodner, Richard D., Huang, Meng-Er
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Academy of Sciences 2007
Schlagworte:
Biological Sciences
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1887571/
https://ncbi.nlm.nih.gov/pubmed/17535927
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0703192104
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