Loss of the Thioredoxin Reductase Trr1 Suppresses the Genomic Instability of Peroxiredoxin tsa1 Mutants

The absence of Tsa1, a key peroxiredoxin that scavenges H(2)O(2) in Saccharomyces cerevisiae, causes the accumulation of a broad spectrum of mutations. Deletion of TSA1 also causes synthetic lethality in combination with mutations in RAD51 or several key genes involved in DNA double-strand break rep...

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Detalhes bibliográficos
Main Authors: Ragu, Sandrine, Dardalhon, Michèle, Sharma, Sushma, Iraqui, Ismail, Buhagiar-Labarchède, Géraldine, Grondin, Virginie, Kienda, Guy, Vernis, Laurence, Chanet, Roland, Kolodner, Richard D., Huang, Meng-Er, Faye, Gérard
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2014
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4172583/
https://ncbi.nlm.nih.gov/pubmed/25247923
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0108123
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