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Oxygen metabolism and reactive oxygen species cause chromosomal rearrangements and cell death
The absence of Tsa1, a key peroxiredoxin that functions to scavenge H(2)O(2) in Saccharomyces cerevisiae, causes the accumulation of a broad spectrum of mutations including gross chromosomal rearrangements (GCRs). Deletion of TSA1 also causes synthetic lethality in combination with mutations in RAD6...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2007
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1887571/ https://ncbi.nlm.nih.gov/pubmed/17535927 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0703192104 |
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