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Antiproliferative effects of novel, nonanticoagulant heparin derivatives on vascular smooth muscle cells in vitro and in vivo.

The proliferation of vascular smooth muscle cells (VSMC) is strongly inhibited by whole heparin both in vitro and in vivo. To identify and characterize antiproliferative, but nonanticoagulant heparin derivatives, heparin fragments made by periodate treatment were produced and acylated with 2-, 4-, o...

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Detalhes bibliográficos
Main Authors: Pukac, L. A., Hirsch, G. M., Lormeau, J. C., Petitou, M., Choay, J., Karnovsky, M. J.
Formato: Artigo
Idioma:Inglês
Publicado em: 1991
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1886460/
https://ncbi.nlm.nih.gov/pubmed/1750515
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