A novel translational regulation function for the simian virus 40 large-T antigen gene.

Cells use the interferon-induced, double-stranded-RNA-dependent protein kinase PKR as a defense against virus infections. Upon activation, PKR phosphorylates and thereby inactivates the protein synthesis initiation factor eIF-2, resulting in the cessation of protein synthesis. Viruses have evolved v...

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Detalhes bibliográficos

Publicado no:	J Virol
Principais autores:	Rajan, P, Swaminathan, S, Zhu, J, Cole, C N, Barber, G, Tevethia, M J, Thimmapaya, B
Formato:	Artigo
Idioma:	Inglês
Publicado em:	American Society for Microbiology (ASM) 1995
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC188643/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7815544/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jvi.69.2.785-795.1995
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