A novel translational regulation function for the simian virus 40 large-T antigen gene.

Cells use the interferon-induced, double-stranded-RNA-dependent protein kinase PKR as a defense against virus infections. Upon activation, PKR phosphorylates and thereby inactivates the protein synthesis initiation factor eIF-2, resulting in the cessation of protein synthesis. Viruses have evolved v...

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Autors principals: Rajan, P, Swaminathan, S, Zhu, J, Cole, C N, Barber, G, Tevethia, M J, Thimmapaya, B
Format: Artigo
Idioma:Inglês
Publicat: 1995
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC188643/
https://ncbi.nlm.nih.gov/pubmed/7815544
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