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EP4 mediates PGE(2) dependent cell survival through the PI3 Kinase/AKT pathway
The anti-apoptotic effect of PGE(2) was examined in Jurkat cells (human T-cell leukemia) by incubation with PGE(2) (5nM) prior to treatment with the cancer chemotherapeutic agent camptothecin. Apoptosis was evaluated by caspase-3 activity in cell extracts and flow cytometry of propidium iodide-label...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2007
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1886004/ https://ncbi.nlm.nih.gov/pubmed/17259077 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.prostaglandins.2006.10.005 |
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