Reversal of the interferon-sensitive phenotype of a vaccinia virus lacking E3L by expression of the reovirus S4 gene.

The vaccinia virus (VV) E3L gene, which encodes a potent inhibitor of the interferon (IFN)-induced, double-stranded RNA (dsRNA)-dependent protein kinase, PKR, is thought to be involved in the IFN-resistant phenotype of VV. The E3L gene products, p25 and p20, act as inhibitors of PKR, presumably by b...

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Bibliografiske detaljer

Udgivet i:	J Virol
Principais autores:	Beattie, E, Denzler, K L, Tartaglia, J, Perkus, M E, Paoletti, E, Jacobs, B L
Format:	Artigo
Sprog:	Inglês
Udgivet:	American Society for Microbiology (ASM) 1995
Fag:	Research Article
Online adgang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC188598/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7527085/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jvi.69.1.499-505.1995
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