Crystal Structures of the p21-Activated Kinases PAK4, PAK5, and PAK6 Reveal Catalytic Domain Plasticity of Active Group II PAKs

p21-activated kinases have been classified into two groups based on their domain architecture. Group II PAKs (PAK4–6) regulate a wide variety of cellular functions, and PAK deregulation has been linked to tumor development. Structural comparison of five high-resolution structures comprising all acti...

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Autori principali: Eswaran, Jeyanthy, Lee, Wen Hwa, Debreczeni, Judit É., Filippakopoulos, Panagis, Turnbull, Andrew, Fedorov, Oleg, Deacon, Sean W., Peterson, Jeffrey R., Knapp, Stefan
Natura: Artigo
Lingua:Inglês
Pubblicazione: Cell Press 2007
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC1885963/
https://ncbi.nlm.nih.gov/pubmed/17292838
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.str.2007.01.001
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