Molecular dynamics using atomic-resolution structure reveal structural fluctuations that may lead to polymerization of human Cu–Zn superoxide dismutase

Mutations of the gene encoding Cu–Zn superoxide dismutase (SOD1) cause 20% of the familial cases of the progressive neurodegenerative disease ALS. A growing body of evidence suggests that in familial ALS (FALS) it is the molecular behavior of the metal-depleted SOD1 dimer that leads to a gain of tox...

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Detaylı Bibliyografya
Asıl Yazarlar: Strange, Richard W., Yong, Chin W., Smith, William, Hasnain, S. Samar
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: National Academy of Sciences 2007
Konular:
Biological Sciences
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC1885824/
https://ncbi.nlm.nih.gov/pubmed/17548825
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0703857104
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