Inhibition of the Tissue Factor-Thrombin Pathway Limits Infarct Size after Myocardial Ischemia-Reperfusion Injury by Reducing Inflammation

Functional inhibition of tissue factor (TF) has been shown to improve coronary blood flow after myocardial ischemia/reperfusion (I/R) injury. TF initiates the coagulation protease cascade, resulting in the generation of the serine protease thrombin and fibrin deposition. Thrombin can also contribute...

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Autori principali: Erlich, Jonathan H., Boyle, Edward M., Labriola, Joanne, Kovacich, J. Craig, Santucci, Richard A., Fearns, Colleen, Morgan, Elizabeth N., Yun, Wang, Luther, Thomas, Kojikawa, Osamu, Martin, Thomas R., Pohlman, Timothy H., Verrier, Edward D., Mackman, Nigel
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Investigative Pathology 2000
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Regular Articles
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC1885771/
https://ncbi.nlm.nih.gov/pubmed/11106558
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