Multiplexing siRNAs to compress RNAi-based screen size in human cells

Here we describe a novel strategy using multiplexes of synthetic small interfering RNAs (siRNAs) corresponding to multiple gene targets in order to compress RNA interference (RNAi) screen size. Before investigating the practical use of this strategy, we first characterized the gene-specific RNAi ind...

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Dettagli Bibliografici
Autori principali: Martin, Scott E., Jones, Tamara L., Thomas, Cheryl L., Lorenzi, Philip L., Nguyen, Dac A., Runfola, Timothy, Gunsior, Michele, Weinstein, John N., Goldsmith, Paul K., Lader, Eric, Huppi, Konrad, Caplen, Natasha J.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Oxford University Press 2007
Soggetti:
Methods Online
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC1885663/
https://ncbi.nlm.nih.gov/pubmed/17392344
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkm141
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