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p53 status dictates responses of B lymphomas to monotherapy with proteasome inhibitors

The proapoptotic function of p53 is thought to underlie most anticancer modalities and is also activated in response to oncogenic insults, such as overexpression of the Myc oncoprotein. Here we generated tractable B lymphomas using retroviral transduction of the MYC oncogene into hematopoietic cells...

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Detalles Bibliográficos
Main Authors: Yu, Duonan, Carroll, Martin, Thomas-Tikhonenko, Andrei
Formato: Artigo
Idioma:Inglês
Publicado: American Society of Hematology 2007
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC1885530/
https://ncbi.nlm.nih.gov/pubmed/17284530
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2006-10-050294
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