The flatiron mutation in mouse ferroportin acts as a dominant negative to cause ferroportin disease

Ferroportin disease is caused by mutation of one allele of the iron exporter ferroportin (Fpn/IREG1/Slc40a1/MTP1). All reported human mutations are missense mutations and heterozygous null mutations in mouse Fpn do not recapitulate the human disease. Here we describe the flatiron (ffe) mouse with a...

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Autori principali: Zohn, Irene E., De Domenico, Ivana, Pollock, Andrew, Ward, Diane McVey, Goodman, Jessica F., Liang, Xiayun, Sanchez, Amaru J., Niswander, Lee, Kaplan, Jerry
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society of Hematology 2007
Soggetti:
Hematopoiesis
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC1885502/
https://ncbi.nlm.nih.gov/pubmed/17289807
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2007-01-066068
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