Growth factor independence-1 (Gfi-1) plays a role in mediating specific granule deficiency (SGD) in a patient lacking a gene-inactivating mutation in the C/EBPϵ gene

Neutrophil-specific granule deficiency (SGD) is a rare congenital disorder marked by recurrent bacterial infections. Neutrophils from SGD patients lack secondary and tertiary granules and their content proteins and lack normal neutrophil functions. Gene-inactivating mutations in the C/EBPϵ gene have...

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Detalhes bibliográficos
Main Authors: Khanna-Gupta, Arati, Sun, Hong, Zibello, Theresa, Lee, Han Myung, Dahl, Richard, Boxer, Laurence A., Berliner, Nancy
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2007
Assuntos:
Hematopoiesis
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1885490/
https://ncbi.nlm.nih.gov/pubmed/17244686
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2005-05-022004
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