Statins synergistically potentiate 7-hydroxystaurosporine (UCN-01) lethality in human leukemia and myeloma cells by disrupting Ras farnesylation and activation

Interactions between UCN-01 and HMG-CoA reductase inhibitors (ie, statins) have been examined in human leukemia and myeloma cells. Exposure of U937 and U266 cells to minimally toxic concentrations of UCN-01 and various statins (eg, lovastatin, simvastatin, or fluvastatin) dramatically increased mito...

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Detalhes bibliográficos
Main Authors: Dai, Yun, Khanna, Payal, Chen, Shuang, Pei, Xin-Yan, Dent, Paul, Grant, Steven
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2007
Assuntos:
Neoplasia
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1885487/
https://ncbi.nlm.nih.gov/pubmed/17264303
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2006-09-047076
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