Role of NAD(P)H:Quinone Oxidoreductase 1 in Clofibrate-Mediated Hepatoprotection from Acetaminophen

Mice pretreated with the peroxisome proliferator clofibrate (CFB) are resistant to acetaminophen (APAP) hepatotoxicity. Whereas the mechanism of protection is not entirely known, CFB decreases protein adducts formed by the reactive metabolite of APAP, N-acetyl-p-benzoquinone imine (NAPQI). NAD(P)H:q...

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Main Authors: Moffit, Jeffrey S, Aleksunes, Lauren M, Kardas, Michael J, Slitt, Angela M, Klaassen, Curtis D, Manautou, José E
Format: Artigo
Jezik:Inglês
Izdano: 2006
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC1885461/
https://ncbi.nlm.nih.gov/pubmed/17188792
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.tox.2006.11.052
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