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Role of NAD(P)H:Quinone Oxidoreductase 1 in Clofibrate-Mediated Hepatoprotection from Acetaminophen
Mice pretreated with the peroxisome proliferator clofibrate (CFB) are resistant to acetaminophen (APAP) hepatotoxicity. Whereas the mechanism of protection is not entirely known, CFB decreases protein adducts formed by the reactive metabolite of APAP, N-acetyl-p-benzoquinone imine (NAPQI). NAD(P)H:q...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2006
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1885461/ https://ncbi.nlm.nih.gov/pubmed/17188792 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.tox.2006.11.052 |
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