A hierarchical approach employing metabolic and gene expression profiles to identify the pathways that confer cytotoxicity in HepG2 cells

BACKGROUND: Free fatty acids (FFA) and tumor necrosis factor alpha (TNF-α) have been implicated in the pathogenesis of many obesity-related metabolic disorders. When human hepatoblastoma cells (HepG2) were exposed to different types of FFA and TNF-α, saturated fatty acid was found to be cytotoxic an...

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Hlavní autoři: Li, Zheng, Srivastava, Shireesh, Yang, Xuerui, Mittal, Sheenu, Norton, Paul, Resau, James, Haab, Brian, Chan, Christina
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2007
Témata:
Methodology Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC1885270/
https://ncbi.nlm.nih.gov/pubmed/17498300
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1752-0509-1-21
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