Exposure to thiopurine drugs through breast milk is low based on metabolite concentrations in mother-infant pairs

AIMS: To determine infant exposure to 6-thioguanine and 6-methylmercaptopurine nucleotides (6-TGN and 6-MMPN, respectively) during maternal use of azathioprine in breastfeeding. METHODS: Mother-infant pairs provided blood for determination of 6-TGN and 6-MMPN concentrations, and TPMT genotype. RESUL...

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Detalhes bibliográficos
Main Authors: Gardiner, Sharon J, Gearry, Richard B, Roberts, Rebecca L, Zhang, Mei, Barclay, Murray L, Begg, Evan J
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Science Inc 2006
Assuntos:
Original Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1885151/
https://ncbi.nlm.nih.gov/pubmed/16995866
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1365-2125.2006.02639.x
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