The effect of CYP2J2, CYP3A4, CYP3A5 and the MDR1 (C3435T) polymorphisms and gender on the urinary excretion of the metabolites of the H(1)-receptor antihistamine ebastine: a pilot study

AIMS: To determine the effect of gender and the genetic polymorphisms of CYP2J2, CYP3A4, CYP3A5 and MDR1 on the urinary excretion of the H(1) antihistamine ebastine in healthy subjects. METHODS: Eighty-nine Caucasians were studied. The presence of polymorphisms in genes known to be involved in ebast...

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Detaylı Bibliyografya
Asıl Yazarlar: Gervasini, Guillermo, Vizcaino, Sonia, Carrillo, Juan Antonio, Caballero, Maria Jesus, Benitez, Julio
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Blackwell Science Inc 2006
Konular:
Pharmacogenetics
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC1885094/
https://ncbi.nlm.nih.gov/pubmed/16842392
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1365-2125.2006.02578.x
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