Fluvoxamine impairs single-dose caffeine clearance without altering caffeine pharmacodynamics

BACKGROUND: Coadministration of fluvoxamine impairs the clearance of caffeine and prolongs its elimination half-life, which is attributable to inhibition of CYP1A2 by fluvoxamine. The clinical importance of this interaction is not established. AIM: To evaluate the effects of fluvoxamine on the kinet...

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Autores principales: Culm-Merdek, Kerry E, von Moltke, Lisa L, Harmatz, Jerold S, Greenblatt, David J
Formato: Artigo
Lenguaje:Inglês
Publicado: Blackwell Science Inc 2005
Materias:
Pharmacokinetics-Pharmacodynamics
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC1884944/
https://ncbi.nlm.nih.gov/pubmed/16236038
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1365-2125.2005.02467.x
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