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Pharmacodynamic effect of continuous vs intermittent dosing of dofetilide on QT interval

AIMS: To investigate the pharmacokinetics and pharmacodynamics of dofetilide 1 mg twice daily continuously for 24 days compared with intermittent single dose treatments. METHODS: A randomized, single-blinded, placebo-controlled, parallel-group, multiple-dose study design was utilized. Healthy male v...

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Detalhes bibliográficos
Main Authors: Allen, Michael J, Oliver, Stuart D, Newgreen, Margaret W, Nichols, Donald J
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Science Inc 2002
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1874554/
https://ncbi.nlm.nih.gov/pubmed/11849196
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1046/j.0306-5251.2001.01511.x
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