Enantioselective disposition of lansoprazole in relation to CYP2C19 genotypes in the presence of fluvoxamine

AIMS: Lansoprazole is affected by polymorphism of CYP2C19. The aim of this study was to examine the effects of fluvoxamine, a CYP2C19 inhibitor, on the pharmacokinetics of each lansoprazole enantiomer among three different CYP2C19 genotype groups. METHODS: Eighteen healthy subjects, of whom six each...

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Main Authors: Miura, Masatomo, Tada, Hitoshi, Yasui-Furukori, Norio, Uno, Tsukasa, Sugawara, Kazunobu, Tateishi, Tomonori, Suzuki, Toshio
Format: Artigo
Jezik:Inglês
Izdano: Blackwell Science Inc 2005
Teme:
Drug Disposition
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC1884909/
https://ncbi.nlm.nih.gov/pubmed/15963095
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1365-2125.2005.02381.x
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