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Population pharmacokinetics of orally administered paclitaxel formulated in Cremophor EL

AIM: The vehicle Cremophor EL (CrEL) has been shown to impair the absorption of paclitaxel by micellar entrapment of the drug in the gastrointestinal tract. The goal of this study was to develop a semimechanistic population pharmacokinetic model to study the influence of CrEL on the oral absorption...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: de Jonge, Milly E, Huitema, Alwin DR, Schellens, Jan HM, Rodenhuis, Sjoerd, Beijnen, Jos H
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Blackwell Science Inc 2005
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC1884789/
https://ncbi.nlm.nih.gov/pubmed/15752379
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1365-2125.2004.02325.x
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