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Bioavailabilities of rectal and oral methadone in healthy subjects

AIMS: Rectal administration of methadone may be an alternative to intravenous and oral dosing in cancer pain, but the bioavailability of the rectal route is not known. The aim of this study was to compare the absolute rectal bioavailability of methadone with its oral bioavailability in healthy human...

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Bibliographic Details
Main Authors: Dale, Ola, Sheffels, Pamela, Kharasch, Evan D
Format: Artigo
Language:Inglês
Published: Blackwell Science Inc 2004
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1884589/
https://ncbi.nlm.nih.gov/pubmed/15255797
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1365-2125.2004.02116.x
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