Characterization of human cytochrome P450 enzymes catalyzing domperidone N-dealkylation and hydroxylation in vitro

AIMS: To confirm the identity of the major metabolites of domperidone and to characterize the cytochrome P450s (CYPs) involved in their formation. METHODS: Human liver microsomes (HLMs) were used to characterize the kinetics of domperidone metabolism and liquid chromatography-mass spectrometry to id...

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Detalhes bibliográficos
Main Authors: Ward, Bryan A, Morocho, Alan, Kandil, Abdullah, Galinsky, Raymond E, Flockhart, David A, Desta, Zeruesenay
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Science Inc 2004
Assuntos:
Drug Metabolism
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1884565/
https://ncbi.nlm.nih.gov/pubmed/15327587
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1365-2125.2004.02156.x
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