Inhibitory effect of stiripentol on carbamazepine and saquinavir metabolism in human

AIMS: To characterize the in vitro and in vivo inhibitory effect of stiripentol, a new anticonvulsant, on the metabolism of carbamazepine and saquinavir, which are substrates of CYP3A4. METHODS: Human liver microsomes and cDNA-expressed CYP enzymes were used for the in vitro experiments. Pharmacokin...

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Detalhes bibliográficos
Main Authors: Cazali, N, Tran, A, Treluyer, J M, Rey, E, d'Athis, P, Vincent, J, Pons, G
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Science Inc 2003
Assuntos:
Drug Metabolism
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1884392/
https://ncbi.nlm.nih.gov/pubmed/14651727
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1046/j.1365-2125.2003.01919.x
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