Pharmacokinetics and clinical effects of phenytoin and fosphenytoin in children with severe malaria and status epilepticus

AIMS: Status epilepticus is common in children with severe falciparum malaria and is associated with poor outcome. Phenytoin is often used to control status epilepticus, but its water-soluble prodrug, fosphenytoin, may be more useful as it is easier to administer. We studied the pharmacokinetics and...

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Detalhes bibliográficos
Main Authors: Ogutu, Bernhards R, Newton, Charles R J C, Muchohi, Simon N, Otieno, Godfrey O, Edwards, Geoffrey, Watkins, William M, Kokwaro, Gilbert O
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Science Inc 2003
Assuntos:
Short Communications
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1884335/
https://ncbi.nlm.nih.gov/pubmed/12848783
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1046/j.1365-2125.2003.01829.x
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