Effects of caffeine intake on the pharmacokinetics of melatonin, a probe drug for CYP1A2 activity

AIMS: The aim of this study was to assess the influence of concomitant caffeine intake on the pharmacokinetics of oral melatonin, a probe drug for CYP1A2 activity. METHODS: Twelve healthy subjects, six smokers and six nonsmokers, were given melatonin (6 mg) either alone or in combination with caffei...

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Bibliographic Details
Main Authors: Härtter, Sebastian, Nordmark, Anna, Rose, Dirk-Matthias, Bertilsson, Leif, Tybring, Gunnel, Laine, Kari
Format: Artigo
Language:Inglês
Published: Blackwell Science Inc 2003
Subjects:
Drug Interactions
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1884289/
https://ncbi.nlm.nih.gov/pubmed/14616429
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1046/j.1365-2125.2003.01933.x
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