Effect of the CYP3A4 inhibitor erythromycin on the pharmacokinetics of lignocaine and its pharmacologically active metabolites in subjects with normal and impaired liver function

AIMS: The objectives of this study were: (i) to evaluate the effect of a cytochrome P450 (CYP) 3A4 inhibitor, erythromycin, on the pharmacokinetics of intravenous lignocaine and its two pharmacologically active metabolites, monoethylglycinexylidide (MEGX) and glycinexylidide (GX); (ii) to assess whe...

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Bibliographic Details
Main Authors: Orlando, Rocco, Piccoli, Pierpaolo, De Martin, Sara, Padrini, Roberto, Palatini, Pietro
Format: Artigo
Language:Inglês
Published: Blackwell Science Inc 2003
Subjects:
Drug Interactions
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1884183/
https://ncbi.nlm.nih.gov/pubmed/12534644
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1046/j.1365-2125.2003.01718.x
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