An open-label study to estimate the effect of steady-state erythromycin on the pharmacokinetics, pharmacodynamics, and safety of a single dose of rivaroxaban in subjects with renal impairment and normal renal function

Two previously conducted rivaroxaban studies showed that, separately, renal impairment (RI) and concomitant administration of erythromycin (P-glycoprotein and moderate cytochrome P450 3A4 [CYP3A4] inhibitor) can result in increases in rivaroxaban exposure. However, these studies did not assess the p...

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Bibliographic Details
Published in:J Clin Pharmacol
Main Authors: Moore, Kenneth T, Vaidyanathan, Seema, Natarajan, Jaya, Ariyawansa, Jay, Haskell, Lloyd, Turner, Kenneth C
Format: Artigo
Language:Inglês
Published: BlackWell Publishing Ltd 2014
Subjects:
Drug-Drug Interactions
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4241044/
https://ncbi.nlm.nih.gov/pubmed/24964176
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jcph.352
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