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Simulation of amoxicillin pharmacokinetics in humans for the prevention of streptococcal endocarditis in rats.

The pharmacokinetic determinants of successful antibiotic prophylaxis of endocarditis are not precisely known. Differences in half-lives of antibiotics between animals and humans preclude extrapolation of animal results to human situations. To overcome this limitation, we have mimicked in rats the a...

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Main Authors: Fluckiger, U, Moreillon, P, Blaser, J, Bickle, M, Glauser, M P, Francioli, P
Format: Artigo
Jezik:Inglês
Izdano: 1994
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC188295/
https://ncbi.nlm.nih.gov/pubmed/7695272
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