Increased antifungal activity of L-733,560, a water-soluble, semisynthetic pneumocandin, is due to enhanced inhibition of cell wall synthesis.

The pneumocandins are natural lipopeptide products of the echinocandin class which inhibit the synthesis of 1,3-beta-D-glucan in susceptible fungi. The lack of a corresponding pathway in mammalian hosts makes this mode of action an attractive one for treating systemic infections. Substitution by an...

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Detalhes bibliográficos

Publicado no:	Antimicrob Agents Chemother
Principais autores:	Kurtz, M B, Douglas, C, Marrinan, J, Nollstadt, K, Onishi, J, Dreikorn, S, Milligan, J, Mandala, S, Thompson, J, Balkovec, J M
Formato:	Artigo
Idioma:	Inglês
Publicado em:	American Society for Microbiology (ASM) 1994
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC188280/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7695257/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.38.12.2750
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