Increased antifungal activity of L-733,560, a water-soluble, semisynthetic pneumocandin, is due to enhanced inhibition of cell wall synthesis.

The pneumocandins are natural lipopeptide products of the echinocandin class which inhibit the synthesis of 1,3-beta-D-glucan in susceptible fungi. The lack of a corresponding pathway in mammalian hosts makes this mode of action an attractive one for treating systemic infections. Substitution by an...

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Detalhes bibliográficos
Main Authors: Kurtz, M B, Douglas, C, Marrinan, J, Nollstadt, K, Onishi, J, Dreikorn, S, Milligan, J, Mandala, S, Thompson, J, Balkovec, J M
Formato: Artigo
Idioma:Inglês
Publicado em: 1994
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC188280/
https://ncbi.nlm.nih.gov/pubmed/7695257
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