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New semisynthetic pneumocandins with improved efficacies against Pneumocystis carinii in the rat.

A new series of semisynthetic, water-soluble pneumocandin analogs has been found to be extremely potent against Pneumocystis carinii in an immunocompromised-rat model. These compounds are 5 to 10 times more potent than the parent natural product, pneumocandin B0 (L-688,786) (R. E. Schwartz et al., J...

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Détails bibliographiques
Auteurs principaux: Schmatz, D M, Powles, M A, McFadden, D, Nollstadt, K, Bouffard, F A, Dropinski, J F, Liberator, P, Andersen, J
Format: Artigo
Langue:Inglês
Publié: 1995
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC162734/
https://ncbi.nlm.nih.gov/pubmed/7574523
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