New semisynthetic pneumocandins with improved efficacies against Pneumocystis carinii in the rat.

A new series of semisynthetic, water-soluble pneumocandin analogs has been found to be extremely potent against Pneumocystis carinii in an immunocompromised-rat model. These compounds are 5 to 10 times more potent than the parent natural product, pneumocandin B0 (L-688,786) (R. E. Schwartz et al., J...

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Publicado en:	Antimicrob Agents Chemother
Autores principales:	Schmatz, D M, Powles, M A, McFadden, D, Nollstadt, K, Bouffard, F A, Dropinski, J F, Liberator, P, Andersen, J
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	American Society for Microbiology (ASM) 1995
Materias:	Research Article
Acceso en línea:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC162734/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7574523/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.39.6.1320
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