Zidovudine–didanosine coexposure potentiates DNA incorporation of zidovudine and mutagenesis in human cells

Drug combinations that include nucleoside reverse transcriptase inhibitors (NRTIs) are remarkably effective in preventing maternal-viral transmission of HIV during pregnancy. However, there may be potential long-term risks for children exposed in utero. Examination of the genotoxic and mutagenic eff...

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Detalhes bibliográficos

Publicado no:	Proc Natl Acad Sci U S A
Principais autores:	Meng, Quanxin, Walker, Dale M., Olivero, Ofelia A., Shi, Xiaochu, Antiochos, Brendan B., Poirier, Miriam C., Walker, Vernon E.
Formato:	Artigo
Idioma:	Inglês
Publicado em:	National Academy of Sciences 2000
Assuntos:	Biological Sciences
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC18821/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11058153/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.220203197
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