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Intracellular metabolism of (-)- and (+)-cis-5-fluoro-1-[2-(hydroxymethyl)-1,3-oxathiolan-5-yl]cytosine in HepG2 derivative 2.2.15 (subclone P5A) cells.

The (-) and (+) enantiomers of the nucleoside analog cis-5-fluoro-1-[2-(hydroxymethyl)-1,3-oxathiolan-5-yl]cytosine (2',3'-dideoxy-5-fluoro-3'-thiacytidine; FTC) have been shown to inhibit hepatitis B virus replication in vitro in HepG2 derivative 2.2.15 (subclone P5A) cells. (-)-FTC and (+)-FTC wer...

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Udgivet i:Antimicrob Agents Chemother
Principais autores: Paff, M T, Averett, D R, Prus, K L, Miller, W H, Nelson, D J
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology (ASM) 1994
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC188191/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8092819/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.38.6.1230
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