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Two tandem verprolin homology domains are necessary for a strong activation of Arp2/3 complex-induced actin polymerization and induction of microspike formation by N-WASP

All WASP family proteins share a common C terminus that consists of the verprolin homology domain (V), cofilin homology domain (C), and acidic region (A), through which they activate Arp2/3 complex-induced actin polymerization. In this study, we characterized the Arp2/3 complex-mediated actin polyme...

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Autors principals: Yamaguchi, Hideki, Miki, Hiroaki, Suetsugu, Shiro, Ma, Le, Kirschner, Marc W., Takenawa, Tadaomi
Format: Artigo
Idioma:Inglês
Publicat: The National Academy of Sciences 2000
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC18815/
https://ncbi.nlm.nih.gov/pubmed/11058146
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