MDM2 inhibits p300-mediated p53 acetylation and activation by forming a ternary complex with the two proteins

p300 acetylates and activates the tumor suppressor p53 after DNA damage. Here, we show that MDM2, a negative-feedback regulator of p53, inhibited p300-mediated p53 acetylation by complexing with these two proteins. First, we purified a p300–MDM2–p53 protein complex from HeLa nuclear extracts, which...

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Bibliographic Details
Main Authors: Kobet, Eric, Zeng, Xiaoya, Zhu, Yong, Keller, David, Lu, Hua
Format: Artigo
Language:Inglês
Published: The National Academy of Sciences 2000
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC18801/
https://ncbi.nlm.nih.gov/pubmed/11070080
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