Chimeric double-stranded RNA-specific adenosine deaminase ADAR1 proteins reveal functional selectivity of double-stranded RNA-binding domains from ADAR1 and protein kinase PKR

The RNA-specific adenosine deaminase (ADAR1) and the RNA-dependent protein kinase (PKR) are both interferon-inducible double-stranded (ds) RNA-binding proteins. ADAR1, an RNA editing enzyme that converts adenosine to inosine, possesses three copies of a dsRNA-binding motif (dsRBM). PKR, a regulator...

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Bibliographic Details
Main Authors: Liu, Yong, Lei, Ming, Samuel, Charles E.
Format: Artigo
Language:Inglês
Published: The National Academy of Sciences 2000
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC18800/
https://ncbi.nlm.nih.gov/pubmed/11070079
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