Double-stranded RNA deaminase ADAR1 promotes the Zika virus replication by inhibiting the activation of protein kinase PKR

Zika virus (ZIKV) is a mosquito-borne flavivirus that has emerged as a threat to global health. The family of adenosine deaminases acting on dsRNA (ADARs) are human host factors important for the genetic diversity and evolution of ZIKV. Here, we further investigated the role of ADAR1 in ZIKV replica...

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Udgivet i:J Biol Chem
Main Authors: Zhou, Shili, Yang, Chao, Zhao, Fanfan, Huang, Yanxia, Lin, Yuxia, Huang, Changbai, Ma, Xiaocao, Du, Jingjie, Wang, Yi, Long, Gang, He, Junfang, Liu, Chao, Zhang, Ping
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2019
Fag:
Microbiology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6885634/
https://ncbi.nlm.nih.gov/pubmed/31636123
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA119.009113
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