The hypoxia-inducible factor α pathway couples angiogenesis to osteogenesis during skeletal development

Skeletal development and turnover occur in close spatial and temporal association with angiogenesis. Osteoblasts are ideally situated in bone to sense oxygen tension and respond to hypoxia by activating the hypoxia-inducible factor α (HIFα) pathway. Here we provide evidence that HIFα promotes angiog...

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Detalhes bibliográficos
Main Authors: Wang, Ying, Wan, Chao, Deng, Lianfu, Liu, Ximeng, Cao, Xuemei, Gilbert, Shawn R., Bouxsein, Mary L., Faugere, Marie-Claude, Guldberg, Robert E., Gerstenfeld, Louis C., Haase, Volker H., Johnson, Randall S., Schipani, Ernestina, Clemens, Thomas L.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2007
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1878533/
https://ncbi.nlm.nih.gov/pubmed/17549257
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI31581
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