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Active Arf6 Recruits ARNO/Cytohesin GEFs to the PM by Binding Their PH Domains

ARNO is a soluble guanine nucleotide exchange factor (GEF) for the Arf family of GTPases. Although in biochemical assays ARNO prefers Arf1 over Arf6 as a substrate, its localization in cells at the plasma membrane (PM) suggests an interaction with Arf6. In this study, we found that ARNO activated Ar...

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Detalhes bibliográficos
Main Authors: Cohen, Lee Ann, Honda, Akira, Varnai, Peter, Brown, Fraser D., Balla, Tamas, Donaldson, Julie G.
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society for Cell Biology 2007
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1877112/
https://ncbi.nlm.nih.gov/pubmed/17409355
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1091/mbc.E06-11-0998
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