Overexpression of VEGF 121 in Immortalized Endothelial Cells Causes Conversion to Slowly Growing Angiosarcoma and High Level Expression of the VEGF Receptors VEGFR-1 and VEGFR-2 in Vivo

Vascular endothelial growth factor (VEGF or vascular permeability factor) is an important angiogenic factor that is up-regulated in numerous benign and malignant disorders, including angiosarcoma, hemangiomas, and solid tumors. To determine the functional role of VEGF in the development of endotheli...

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Bibliographische Detailangaben
Hauptverfasser: Arbiser, Jack L., Larsson, Helena, Claesson-Welsh, Lena, Bai, Xianhe, LaMontagne, Kenneth, Weiss, Sharon W., Soker, Shai, Flynn, Evelyn, Brown, Lawrence F.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Investigative Pathology 2000
Schlagworte:
Animal Models
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1876889/
https://ncbi.nlm.nih.gov/pubmed/10751370
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