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GATA6 is an astrocytoma tumor suppressor gene identified by gene trapping of mouse glioma model

Malignant astrocytomas are the most common and lethal adult primary brain tumor. Retroviral gene trapping of nontransformed neonatal astrocytes from a glial fibrillary acidic protein (GFAP):(V12)Ha-Ras murine astrocytoma model led to isolation of the transcription factor Gata6. Loss of Gata6 resulte...

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Autores principales: Kamnasaran, Deepak, Qian, Baoping, Hawkins, Cynthia, Stanford, William L., Guha, Abhijit
Formato: Artigo
Lenguaje:Inglês
Publicado: National Academy of Sciences 2007
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC1876570/
https://ncbi.nlm.nih.gov/pubmed/17463088
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0611669104
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