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GATA6 is an astrocytoma tumor suppressor gene identified by gene trapping of mouse glioma model

Malignant astrocytomas are the most common and lethal adult primary brain tumor. Retroviral gene trapping of nontransformed neonatal astrocytes from a glial fibrillary acidic protein (GFAP):(V12)Ha-Ras murine astrocytoma model led to isolation of the transcription factor Gata6. Loss of Gata6 resulte...

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Detalhes bibliográficos
Main Authors: Kamnasaran, Deepak, Qian, Baoping, Hawkins, Cynthia, Stanford, William L., Guha, Abhijit
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2007
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1876570/
https://ncbi.nlm.nih.gov/pubmed/17463088
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0611669104
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