Pathological and Molecular Progression of Astrocytomas in a GFAP:(12)V-Ha-Ras Mouse Astrocytoma Model

We previously characterized a genetically engineered mouse astrocytoma model with embryonic astrocyte-specific, activated (12)V-Ha-RAS (GFAP-RAS) transgenesis. The GFAP-RAS line Ras-B8 appears normal at birth, but 50% of mice die by 4 months from low- and high-grade astrocytomas. We examined the dev...

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Hauptverfasser: Shannon, Patrick, Sabha, Nesrin, Lau, Nelson, Kamnasaran, Deepak, Gutmann, David H., Guha, Abhijit
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Investigative Pathology 2005
Schlagworte:
Original Research Paper
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1698742/
https://ncbi.nlm.nih.gov/pubmed/16127163
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